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Type: Journal article
Title: Relationship between serum RANKL and RANKL in bone
Author: Findlay, D.
Atkins, G.
Citation: Osteoporosis International, 2011; 22(10):2597-2602
Publisher: Springer London Ltd
Issue Date: 2011
ISSN: 0937-941X
Statement of
D. M. Findlay, G. J. Atkins
Abstract: It is now well accepted that the molecule receptor activator of NFκB ligand (RANKL) and osteoprotegerin play key roles in regulating physiological and pathological bone turnover. There are a large number of published reports of circulating RANKL levels in both health and pathology. However, interpretation of these data has been elusive, and the relationship between circulating RANKL and RANKL levels in bone is still not clear. This review explores this subject, documenting the possible origins of circulating RANKL and suggesting additional information that is required before serum RANKL levels can provide useful diagnostic or research information.
Keywords: Bone; mRNA; RANK ligand; Serum
Rights: © International Osteoporosis Foundation and National Osteoporosis Foundation 2011
RMID: 0020112615
DOI: 10.1007/s00198-011-1740-9
Appears in Collections:Orthopaedics and Trauma publications

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