Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/6684
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dc.contributor.authorHaynes, D.en
dc.contributor.authorBoyle, S.en
dc.contributor.authorRogers, S.en
dc.contributor.authorHowie, D.en
dc.contributor.authorVernon-Roberts, B.en
dc.date.issued1998en
dc.identifier.citationClinical Orthopaedics and Related Research, 1998; 352(352):223-230en
dc.identifier.issn0009-921Xen
dc.identifier.issn1528-1132en
dc.identifier.urihttp://hdl.handle.net/2440/6684-
dc.description.abstractParticles of prosthetic material stimulate macrophages to release cytokines, which may cause bone loss and loosening of the prosthesis. This study investigates the possibility that particles of different prosthetic materials may induce different cytokines and thus have different effects on bone remodeling. The in vitro response of human monocytes to particles of cast and forged cobalt chrome alloy, stainless steel, and titanium aluminum vanadium alloy were compared. There was no difference in the biologic response to cobalt-chrome particles derived from cast or forged material. Cobalt-chrome particles were toxic to the cells, but titanium aluminum vanadium particles did not affect cell viability. Stainless steel particles were approximately 10 times more toxic than were cobalt-chrome particles. All particles induced the release of tumor necrosis factor and interleukin 1 beta; stainless steel particles were the most potent stimulators of interleukin 1 beta; titanium aluminum vanadium particles were the strongest stimulators of interleukin 6 and prostaglandin 2. The study showed that particles derived from prosthetic materials of different metal compositions can elicit significantly different biologic responses. Understanding these different responses may help identify materials better suited for prostheses.en
dc.language.isoenen
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen
dc.subjectMonocytes; Cells, Cultured; Humans; Chromium Alloys; Titanium; Stainless Steel; Alloys; Dinoprostone; Tumor Necrosis Factor-alpha; Interleukin-1; Interleukin-6; Cytokines; Biocompatible Materials; Particle Size; Female; Maleen
dc.titleVariation in cytokines induced by particles from different prosthetic materialsen
dc.typeJournal articleen
dc.identifier.rmid0030005856en
dc.identifier.pubid69862-
pubs.library.collectionOrthopaedics and Trauma publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidHowie, D. [0000-0003-1702-3279]en
Appears in Collections:Orthopaedics and Trauma publications

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