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dc.contributor.authorBeste, C.en
dc.contributor.authorKolev, V.en
dc.contributor.authorYordanova, J.en
dc.contributor.authorDomschke, K.en
dc.contributor.authorFalkenstein, M.en
dc.contributor.authorBaune, B.en
dc.contributor.authorKonrad, C.en
dc.identifier.citationJournal of Neuroscience, 2010; 30(32):10727-10733en
dc.description.abstractBehavioral adaptation depends on the recognition of response errors and processing of this error-information. Error processing is a specific cognitive function crucial for behavioral adaptation. Neurophysiologically, these processes are reflected by an event-related potential (ERP), the error negativity (Ne/ERN). Even though synchronization processes are important in information processing, its role and neurobiological foundation in behavioral adaptation are not understood. The brain-derived neurotrophic factor (BDNF) strongly modulates the establishment of neural connectivity that determines neural network dynamics and synchronization properties. Therefore altered synchronization processes may constitute a mechanism via which BDNF affects processes of error-induced behavioral adaptation. We investigate how variants of the BDNF gene regulate EEG-synchronization processes underlying error processing. Subjects (n = 65) were genotyped for the functional BDNF Val66Met polymorphism (rs6265). We show that Val/Val genotype is associated with stronger error-specific phase-locking, compared with Met allele carriers. Posterror behavioral adaptation seems to be strongly dependent on these phase-locking processes and efficacy of EEG-phase-locking-behavioral coupling was genotype dependent. After correct responses, neurophysiological processes were not modulated by the polymorphism, underlining that BDNF becomes especially necessary in situations requiring behavioral adaptation. The results suggest that alterations in neural synchronization processes modulated by the genetic variants of BDNF Val66Met may be the mechanism by which cognitive functions are affected.en
dc.description.statementofresponsibilityChristian Beste, Vasil Kolev, Juliana Yordanova, Katharina Domschke, Michael Falkenstein, Bernhard T. Baune and Carsten Konraden
dc.publisherSoc Neuroscienceen
dc.rightsCopyright © 2010 the authorsen
dc.subjectNeural Pathways; Humans; Brain-Derived Neurotrophic Factor; Valine; Methionine; Electroencephalography; Brain Mapping; Spectrum Analysis; Analysis of Variance; Photic Stimulation; Reaction Time; Neuropsychological Tests; Contingent Negative Variation; Evoked Potentials, Visual; Gene Frequency; Genotype; Polymorphism, Genetic; Time Factors; Adult; Female; Male; Young Adulten
dc.titleThe Role of the BDNF Val66Met Polymorphism for the Synchronization of Error-Specific Neural Networksen
dc.typeJournal articleen
pubs.library.collectionPsychiatry publicationsen
dc.identifier.orcidBaune, B. [0000-0001-6548-426X]en
Appears in Collections:Psychiatry publications

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