Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/66047
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Type: Journal article
Title: The role of the BDNF Val66Met polymorphism for the synchronization of error-specific neural networks
Author: Beste, C.
Kolev, V.
Yordanova, J.
Domschke, K.
Falkenstein, M.
Baune, B.
Konrad, C.
Citation: The Journal of Neuroscience, 2010; 30(32):10727-10733
Publisher: Society for Neuroscience
Issue Date: 2010
ISSN: 0270-6474
1529-2401
Statement of
Responsibility: 
Christian Beste, Vasil Kolev, Juliana Yordanova, Katharina Domschke, Michael Falkenstein, Bernhard T. Baune, and Carsten Konrad
Abstract: Behavioral adaptation depends on the recognition of response errors and processing of this error-information. Error processing is a specific cognitive function crucial for behavioral adaptation. Neurophysiologically, these processes are reflected by an event-related potential (ERP), the error negativity (Ne/ERN). Even though synchronization processes are important in information processing, its role and neurobiological foundation in behavioral adaptation are not understood. The brain-derived neurotrophic factor (BDNF) strongly modulates the establishment of neural connectivity that determines neural network dynamics and synchronization properties. Therefore altered synchronization processes may constitute a mechanism via which BDNF affects processes of error-induced behavioral adaptation. We investigate how variants of the BDNF gene regulate EEG-synchronization processes underlying error processing. Subjects (n = 65) were genotyped for the functional BDNF Val66Met polymorphism (rs6265). We show that Val/Val genotype is associated with stronger error-specific phase-locking, compared with Met allele carriers. Posterror behavioral adaptation seems to be strongly dependent on these phase-locking processes and efficacy of EEG-phase-locking-behavioral coupling was genotype dependent. After correct responses, neurophysiological processes were not modulated by the polymorphism, underlining that BDNF becomes especially necessary in situations requiring behavioral adaptation. The results suggest that alterations in neural synchronization processes modulated by the genetic variants of BDNF Val66Met may be the mechanism by which cognitive functions are affected.
Keywords: Neural Pathways
Humans
Brain-Derived Neurotrophic Factor
Valine
Methionine
Electroencephalography
Brain Mapping
Spectrum Analysis
Analysis of Variance
Photic Stimulation
Reaction Time
Neuropsychological Tests
Contingent Negative Variation
Evoked Potentials, Visual
Gene Frequency
Genotype
Polymorphism, Genetic
Time Factors
Adult
Female
Male
Young Adult
Rights: Copyright © 2010 the authors. Authors grant JNeurosci a license to publish their work and copyright remains with the author. Material published from 2010 to 2014 is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License (CC-BY-NC-SA).
DOI: 10.1523/JNEUROSCI.2493-10.2010
Published version: http://dx.doi.org/10.1523/jneurosci.2493-10.2010
Appears in Collections:Aurora harvest 5
Psychiatry publications

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