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Type: Journal article
Title: HTR2A gene variation is involved in antidepressant treatment response
Author: Lucae, S.
Ising, M.
Horstmann, S.
Baune, B.
Arolt, V.
Muller-Myhsok, B.
Holsboer, F.
Domschke, K.
Citation: European Neuropsychopharmacology, 2010; 20(1):65-68
Publisher: Elsevier Science BV
Issue Date: 2010
ISSN: 0924-977X
Statement of
Susanne Lucae, Marcus Ising, Sonja Horstmann, Bernhard T. Baune, Volker Arolt, Bertram Müller-Myhsok, Florian Holsboer, Katharina Domschke
Abstract: Two serotonin 2A receptor (HTR2A) SNPs recently reported to be associated with antidepressant treatment response in STARD (rs7997012; rs1928040) were analyzed for association with treatment response in two independent Caucasian samples of patients with a Major Depressive Episode. In the combined sample (n=637) SNP rs7997012 was significantly associated with remission after five weeks providing first replicative support for the initial finding, with, however, an inverse allelic association as compared to the STARD sample.
Keywords: HTR2A; Pharmacogenetics; SNP; Treatment response; Major Depression; Association study
Rights: © 2009 Elsevier B.V. and ECNP All rights reserved.
RMID: 0020111493
DOI: 10.1016/j.euroneuro.2009.08.006
Appears in Collections:Psychiatry publications

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