Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/65742
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Medical Comorbidity Affects Antidepressant Treatment Response in Patients with Melancholic Depression |
Author: | Pohle, K. Domschke, K. Roehrs, T. Arolt, V. Baune, B. |
Citation: | Psychotherapy and Psychosomatics, 2009; 78(6):359-363 |
Publisher: | Karger |
Issue Date: | 2009 |
ISSN: | 0033-3190 1423-0348 |
Statement of Responsibility: | K. Pohle, K. Domschke, T. Roehrs, V. Arolt, B.T. Baune |
Abstract: | <h4>Background</h4>This study aimed at the impact of medical comorbidity (MC) on response to antidepressant treatment over 6 weeks in diagnostic subtypes of patients with major depressive episode (MDE).<h4>Methods</h4>In a clinical sample of 241 admitted patients with MDE, MC was assessed by medical specialists and weekly response to antidepressant treatment was assessed with the Hamilton Depression Scale (HAM-D 21).<h4>Results</h4>Over 6 weeks of treatment, patients with melancholic depression and MC had poorer treatment response on the HAM-D scale and a worse functional outcome (GAF) as opposed to their counterparts without MC, which was first detected after 4 weeks of treatment (p = 0.02). More specifically, subjects with melancholic depression and cardiovascular or endocrinological MC showed significantly poorer treatment response over 6 weeks. Interestingly, these effects were not related to various antidepressant treatment regimens.<h4>Conclusions</h4>MC has a negative impact on treatment response in patients with melancholic depression. |
Keywords: | Medical comorbidity Subtypes of depression Treatment response |
Rights: | © 2009 S. Karger AG, Basel |
DOI: | 10.1159/000235975 |
Published version: | http://dx.doi.org/10.1159/000235975 |
Appears in Collections: | Aurora harvest Psychiatry publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.