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https://hdl.handle.net/2440/65742
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dc.contributor.author | Pohle, K. | - |
dc.contributor.author | Domschke, K. | - |
dc.contributor.author | Roehrs, T. | - |
dc.contributor.author | Arolt, V. | - |
dc.contributor.author | Baune, B. | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Psychotherapy and Psychosomatics, 2009; 78(6):359-363 | - |
dc.identifier.issn | 0033-3190 | - |
dc.identifier.issn | 1423-0348 | - |
dc.identifier.uri | http://hdl.handle.net/2440/65742 | - |
dc.description.abstract | <h4>Background</h4>This study aimed at the impact of medical comorbidity (MC) on response to antidepressant treatment over 6 weeks in diagnostic subtypes of patients with major depressive episode (MDE).<h4>Methods</h4>In a clinical sample of 241 admitted patients with MDE, MC was assessed by medical specialists and weekly response to antidepressant treatment was assessed with the Hamilton Depression Scale (HAM-D 21).<h4>Results</h4>Over 6 weeks of treatment, patients with melancholic depression and MC had poorer treatment response on the HAM-D scale and a worse functional outcome (GAF) as opposed to their counterparts without MC, which was first detected after 4 weeks of treatment (p = 0.02). More specifically, subjects with melancholic depression and cardiovascular or endocrinological MC showed significantly poorer treatment response over 6 weeks. Interestingly, these effects were not related to various antidepressant treatment regimens.<h4>Conclusions</h4>MC has a negative impact on treatment response in patients with melancholic depression. | - |
dc.description.statementofresponsibility | K. Pohle, K. Domschke, T. Roehrs, V. Arolt, B.T. Baune | - |
dc.language.iso | en | - |
dc.publisher | Karger | - |
dc.rights | © 2009 S. Karger AG, Basel | - |
dc.source.uri | http://dx.doi.org/10.1159/000235975 | - |
dc.subject | Medical comorbidity | - |
dc.subject | Subtypes of depression | - |
dc.subject | Treatment response | - |
dc.title | Medical Comorbidity Affects Antidepressant Treatment Response in Patients with Melancholic Depression | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1159/000235975 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Baune, B. [0000-0001-6548-426X] | - |
Appears in Collections: | Aurora harvest Psychiatry publications |
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