Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/65670
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dc.contributor.authorDannlowski, U.en
dc.contributor.authorOhrmann, P.en
dc.contributor.authorKonrad, C.en
dc.contributor.authorDomschke, K.en
dc.contributor.authorBauer, J.en
dc.contributor.authorKugel, H.en
dc.contributor.authorHohoff, C.en
dc.contributor.authorSchoning, S.en
dc.contributor.authorKersting, A.en
dc.contributor.authorBaune, B.en
dc.contributor.authorMortensen, L.en
dc.contributor.authorArolt, V.en
dc.contributor.authorZwitserlood, P.en
dc.contributor.authorDeckert, J.en
dc.contributor.authorHeindel, W.en
dc.contributor.authorSuslow, T.en
dc.date.issued2009en
dc.identifier.citationInternational Journal of Neuropsychopharmacology, 2009; 12(1):11-22en
dc.identifier.issn1461-1457en
dc.identifier.issn1469-5111en
dc.identifier.urihttp://hdl.handle.net/2440/65670-
dc.description.abstractThe amygdala plays a pivotal role in a cortico-limbic circuitry implicated in emotion processing and regulation. In the present study, functional connectivity of the amygdala with prefrontal areas involved in emotion regulation was investigated during a facial expression processing task in a sample of 34 depressed inpatients and 31 healthy controls. All patients were genotyped for a common functional variable number tandem repeat (VNTR) polymorphism in the promoter region of the monoamine oxidase A gene (MAOA u-VNTR) which has been previously associated with major depression as well as reduced cortico-limbic connectivity in healthy subjects. In our control group, we observed tight coupling of the amygdala and dorsal prefrontal areas comprising the dorsolateral prefrontal cortex (DLPFC), dorsal parts of the anterior cingulate cortex (dACC), and lateral orbitofrontal cortex. Amygdala–prefrontal connectivity was significantly reduced in depressed patients and carriers of the higher active MAOA risk alleles (MAOA-H). Hence, depressed MAOA-H carriers showed the weakest amygdala–prefrontal coupling of the investigated subgroups. Furthermore, reduced coupling of this circuitry predicted more than 40% variance of clinical variables characterizing a longer and more severe course of disease. We conclude that genetic variation in the MAOA gene may affect the course of major depression by disrupting cortico-limbic connectivity.en
dc.description.statementofresponsibilityUdo Dannlowski, Patricia Ohrmann, Carsten Konrad, Katharina Domschke, Jochen Bauer, Harald Kugel, Christa Hohoff, Sonja Schöning, Anette Kersting, Bernhard T. Baune, Lena S. Mortensen, Volker Arolt, Pienie Zwitserlood, Jürgen Deckert, Walter Heindel, and Thomas Suslowen
dc.language.isoenen
dc.publisherCambridge Univ Pressen
dc.rightsCopyright © 2008 CINPen
dc.subjectAmygdala; fMRI; genetics; major depression; monoamine oxidase Aen
dc.titleReduced amygdala-prefrontal coupling in major depression: association with MAOA genotype and illness severityen
dc.typeJournal articleen
dc.identifier.rmid0020111500en
dc.identifier.doi10.1017/S1461145708008973en
dc.identifier.pubid28276-
pubs.library.collectionPsychiatry publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidBaune, B. [0000-0001-6548-426X]en
Appears in Collections:Psychiatry publications

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