Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/63562
Type: | Thesis |
Title: | Characterisation of the 5’-flanking region of the CYP27B1 gene in osteoblast-like cells. |
Author: | Turner, Andrew |
Issue Date: | 2007 |
School/Discipline: | School of Molecular and Biomedical Science : Physiology |
Abstract: | This study investigates expression of the 5’-flanking region of the CYP27B1 gene in osteoblast cells. The results demonstrate that the CYP27B1 gene is regulated differently within osteoblast cells to that in kidney and prostate cells. Basal expression of the 5’-flanking region of the CYP27B1 gene involves a complex interaction of enhancer and repressor elements. Furthermore, rather than being regulated by calciotropic agents, CYP27B1 gene expression is controlled by locally secreted growth factors such as TGF-β and IGF-1. These data are consistent with a model whereby synthesis of 1,25(OH)₂D₃ by osteoblasts serves an autocrine or paracrine role. |
Dissertation Note: | Thesis (Ph.D.) - University of Adelaide, School of Molecular and Biomedical Sciences, 2007 |
Keywords: | vitamin D; bone cells |
Provenance: | This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals |
Appears in Collections: | Research Theses |
Files in This Item:
File | Description | Size | Format | |
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01front.pdf | 65.12 kB | Adobe PDF | View/Open | |
02whole.pdf | 8.07 MB | Adobe PDF | View/Open |
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