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Type: Thesis
Title: The role of BMP4 in the Ex vivo expansion of cord blood haemopoietic stem cells.
Author: Hutton, Jonathon Frederick
Issue Date: 2007
School/Discipline: School of Medicine : Medicine
Abstract: Establishment of conditions supporting haemopoietic stem cell (HSC) maintenance and expansion ex vivo is critical for wider clinical application of cord blood (CB) transplantation. AFT024 is a murine fetal liver cell line that expands primitive haemopoietic cells via a process that is not understood. Here we shoe that bone morphogenetic protein (BMP) 4, which is a member of the transforming growth factor-beta super family of pleitropic regulators, is produced by AFT024 and contributes significantly to the maintenance of co-cultured CB-derived primitive cells ... BMP4 can contribute to HSC maintenance both in an established long-term co-culture model and in a clinical ex vivo expansion setting.
Dissertation Note: Thesis (Ph.D.) -- University of Adelaide, School of Medicine, 2007
Keywords: hematopoietic stem cells; hematopoietic stem cells cytology; transforming growth factors-beta.
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