Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/61976
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dc.contributor.authorHutton, Jonathon Fredericken
dc.date.issued2007en
dc.identifier.urihttp://hdl.handle.net/2440/61976-
dc.description.abstractEstablishment of conditions supporting haemopoietic stem cell (HSC) maintenance and expansion ex vivo is critical for wider clinical application of cord blood (CB) transplantation. AFT024 is a murine fetal liver cell line that expands primitive haemopoietic cells via a process that is not understood. Here we shoe that bone morphogenetic protein (BMP) 4, which is a member of the transforming growth factor-beta super family of pleitropic regulators, is produced by AFT024 and contributes significantly to the maintenance of co-cultured CB-derived primitive cells ... BMP4 can contribute to HSC maintenance both in an established long-term co-culture model and in a clinical ex vivo expansion setting.en
dc.subjecthematopoietic stem cells; hematopoietic stem cells cytology; transforming growth factors-beta.en
dc.titleThe role of BMP4 in the Ex vivo expansion of cord blood haemopoietic stem cells.en
dc.typeThesisen
dc.contributor.schoolSchool of Medicine : Medicineen
dc.provenanceThis electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals. Copyright material removed from digital thesis. See print copy in University of Adelaide Library for full text.en
dc.description.dissertationThesis (Ph.D.) -- University of Adelaide, School of Medicine, 2007en
Appears in Collections:Research Theses

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