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dc.contributor.authorFagan, A.en
dc.contributor.authorSarvestani, G.en
dc.contributor.authorMoore, R.en
dc.contributor.authorFraser, R.en
dc.contributor.authorVernon-Roberts, B.en
dc.contributor.authorBlumbergs, P.en
dc.identifier.citationSpine, 2010; 35(12):1200-1205en
dc.description.abstractSTUDY DESIGN: A prospective immunohistological study in an animal model. OBJECTIVE: To identify and describe the phenotype of neoinnervation in experimental anular tears. SUMMARY OF BACKGROUND DATA: Controversy surrounds neoinnervation of degenerate discs which has been proposed as the anatomic basis for discogenic pain. Ablation of neoinnervation has been postulated as the theoretical basis for the claimed successes of procedures such as intradiscal electrotherapy. The animal model of disc degeneration previously developed in our research center provides an opportunity to investigate the innervation of anular tears in an extensively characterized lesion. METHODS: A surgical anular tear was created in 5 lumbar discs in 11 sheep which were killed at 1, 2, 3, and 12 months. Each spine was x-rayed and divided into motion segments for histologic analysis. Serial sections through the tear were immunostained for protein gene product 9.5, tyrosine hydroxylase, and calcitonin gene receptor protein. RESULTS: Neoinnervation of the periphery of the anular tear was observed. Ingrowing nerves penetrated marginally deeper than the normal anular innervation but no nerves were identified in the inner anulus or nucleus. A minority of the new axons were calcitonin gene receptor protein or tyrosine hydroxylase positive. CONCLUSION: The anulus tears in this model are innervated only peripherally to a depth only marginally greater than that of the normal anulus.en
dc.description.statementofresponsibilityAndrew B. Fagan, Ghafar Sarvestani, Robert J. Moore, Robert D. Fraser, Barrie Vernon-Roberts and Peter C. Blumbergsen
dc.publisherLippincott Williams & Wilkinsen
dc.rights© 2010 Lippincott Williams & Wilkins, Inc.en
dc.subjectintervertebral disc; innervation; protein gene product 9.5; tyrosine hydroxylase; calcitonin gene-related peptide; autonomic nervous system; somatic nervous system; substance P; discogenic painen
dc.titleInnervation of anulus tears: An experimental animal studyen
dc.typeJournal articleen
pubs.library.collectionOrthopaedics and Trauma publicationsen
Appears in Collections:Orthopaedics and Trauma publications

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