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Type: Journal article
Title: Innervation of anulus tears: An experimental animal study
Author: Fagan, A.
Sarvestani, G.
Moore, R.
Fraser, R.
Vernon-Roberts, B.
Blumbergs, P.
Citation: Spine, 2010; 35(12):1200-1205
Publisher: Lippincott Williams & Wilkins
Issue Date: 2010
ISSN: 0362-2436
Statement of
Andrew B. Fagan, Ghafar Sarvestani, Robert J. Moore, Robert D. Fraser, Barrie Vernon-Roberts and Peter C. Blumbergs
Abstract: <h4>Study design</h4>A prospective immunohistological study in an animal model.<h4>Objective</h4>To identify and describe the phenotype of neoinnervation in experimental anular tears.<h4>Summary of background data</h4>Controversy surrounds neoinnervation of degenerate discs which has been proposed as the anatomic basis for discogenic pain. Ablation of neoinnervation has been postulated as the theoretical basis for the claimed successes of procedures such as intradiscal electrotherapy. The animal model of disc degeneration previously developed in our research center provides an opportunity to investigate the innervation of anular tears in an extensively characterized lesion.<h4>Methods</h4>A surgical anular tear was created in 5 lumbar discs in 11 sheep which were killed at 1, 2, 3, and 12 months. Each spine was x-rayed and divided into motion segments for histologic analysis. Serial sections through the tear were immunostained for protein gene product 9.5, tyrosine hydroxylase, and calcitonin gene receptor protein.<h4>Results</h4>Neoinnervation of the periphery of the anular tear was observed. Ingrowing nerves penetrated marginally deeper than the normal anular innervation but no nerves were identified in the inner anulus or nucleus. A minority of the new axons were calcitonin gene receptor protein or tyrosine hydroxylase positive.<h4>Conclusion</h4>The anulus tears in this model are innervated only peripherally to a depth only marginally greater than that of the normal anulus.
Keywords: intervertebral disc
protein gene product 9.5
tyrosine hydroxylase
calcitonin gene-related peptide
autonomic nervous system
somatic nervous system
substance P
discogenic pain
Rights: © 2010 Lippincott Williams & Wilkins, Inc.
DOI: 10.1097/BRS.0b013e3181c02812
Appears in Collections:Aurora harvest
Orthopaedics and Trauma publications

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