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Type: Journal article
Title: S100A8/S100A9 and their association with cartilage and bone
Author: Zreiqat, H.
Howlett, C.
Gronthos, S.
Hume, D.
Geczy, C.
Citation: Journal of Molecular Histology, 2007; 38(5):381-391
Publisher: Kluwer Academic Publ
Issue Date: 2007
ISSN: 1567-2379
Statement of
H. Zreiqat, C. R. Howlett, S. Gronthos, D. Hume and C. L. Geczy
Abstract: S100A8 and S100A9 are calcium-binding proteins expressed in myeloid cells and are markers of numerous inflammatory diseases in humans. S100A9 has been associated with dystrophic calcification in human atherosclerosis. Here we demonstrate S100A8 and S100A9 expression in murine and human bone and cartilage cells. Only S100A8 was seen in preosteogenic cells whereas osteoblasts had variable, but generally weak expression of both proteins. In keeping with their reported high-mRNA expression, S100A8 and S100A9 were prominent in osteoclasts. S100A8 was expressed in alkaline phosphatase-positive hypertrophic chondrocytes, but not in proliferating chondrocytes within the growth plate where the cartilaginous matrix was calcifying. S100A9 was only evident in the invading vascular osteogenic tissue penetrating the degenerating chondrocytic zone adjacent to the primary spongiosa, where S100A8 was also expressed. Whilst, S100A8 has been shown to be associated with osteoblast differentiation, both S100A8 and S100A9 may contribute to calcification of the cartilage matrix and its replacement with trabecular bone, and to regulation of redox in bone resorption.
Keywords: S100A8
Rights: © Springer Science+Business Media B.V. 2007
DOI: 10.1007/s10735-007-9117-2
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