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https://hdl.handle.net/2440/60425
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dc.contributor.author | Alexander, D. | - |
dc.contributor.author | Flynn, G. | - |
dc.contributor.author | Wong, W. | - |
dc.contributor.author | Whitford, T. | - |
dc.contributor.author | Harris, A. | - |
dc.contributor.author | Galletly, C. | - |
dc.contributor.author | Silverstein, S. | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Clinical Neurophysiology, 2009; 120(9):1667-1682 | - |
dc.identifier.issn | 1388-2457 | - |
dc.identifier.issn | 1872-8952 | - |
dc.identifier.uri | http://hdl.handle.net/2440/60425 | - |
dc.description.abstract | <h4>Objective</h4>Schizophrenia is characterized by a deficit in context processing, with physiological correlates of hypofrontality and reduced amplitude P3b event-related potentials. We hypothesized an additional physiological correlate: differences in the spatio-temporal dynamics of cortical activity along the anterior-posterior axis of the scalp.<h4>Methods</h4>This study assessed latency topographies of spatio-temporal waves under task conditions that elicit the P3b. EEG was recorded during separate auditory and visual tasks. Event-related spatio-temporal waves were quantified from scalp EEG of subjects with first episode schizophrenia (FES) and matched controls.<h4>Results</h4>The P3b-related task conditions elicited a peak in spatio-temporal waves in the delta band at a similar latency to the P3b event-related potential. Subjects with FES had fewer episodes of anterior to posterior waves in the 2-4 Hz band compared to controls. Within the FES group, a tendency for fewer episodes of anterior to posterior waves was associated with high Psychomotor Poverty symptom factor scores.<h4>Conclusions</h4>Subjects with FES had altered global EEG dynamics along the anterior-posterior axis during task conditions involving context update.<h4>Significance</h4>The directional nature of this finding and its association with Psychomotor Poverty suggest this result is related to findings of hypofrontality in schizophrenia. | - |
dc.description.statementofresponsibility | David M. Alexander, Gary J. Flynn, Wilson Wong, Thomas J. Whitford, Anthony W.F. Harris, Cherrie A. Galletly and Steven M. Silverstein | - |
dc.description.uri | http://www.elsevier.com/wps/find/journaldescription.cws_home/601528/description#description | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Sci Ireland Ltd | - |
dc.rights | Crown Copyright Copyright 2009 Published by Elsevier Ireland Ltd. on behalf of International Federation of Clinical Neurobiology. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.clinph.2009.06.020 | - |
dc.subject | Schizophrenia | - |
dc.subject | EEG dynamics | - |
dc.subject | P3b ERP | - |
dc.subject | Psychomotor Poverty | - |
dc.subject | Hypofrontality | - |
dc.title | Spatio-temporal EEG waves in first episode schizophrenia | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.clinph.2009.06.020 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Galletly, C. [0000-0001-6185-9677] | - |
Appears in Collections: | Aurora harvest Psychiatry publications |
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