Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/60425
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dc.contributor.authorAlexander, D.-
dc.contributor.authorFlynn, G.-
dc.contributor.authorWong, W.-
dc.contributor.authorWhitford, T.-
dc.contributor.authorHarris, A.-
dc.contributor.authorGalletly, C.-
dc.contributor.authorSilverstein, S.-
dc.date.issued2009-
dc.identifier.citationClinical Neurophysiology, 2009; 120(9):1667-1682-
dc.identifier.issn1388-2457-
dc.identifier.issn1872-8952-
dc.identifier.urihttp://hdl.handle.net/2440/60425-
dc.description.abstract<h4>Objective</h4>Schizophrenia is characterized by a deficit in context processing, with physiological correlates of hypofrontality and reduced amplitude P3b event-related potentials. We hypothesized an additional physiological correlate: differences in the spatio-temporal dynamics of cortical activity along the anterior-posterior axis of the scalp.<h4>Methods</h4>This study assessed latency topographies of spatio-temporal waves under task conditions that elicit the P3b. EEG was recorded during separate auditory and visual tasks. Event-related spatio-temporal waves were quantified from scalp EEG of subjects with first episode schizophrenia (FES) and matched controls.<h4>Results</h4>The P3b-related task conditions elicited a peak in spatio-temporal waves in the delta band at a similar latency to the P3b event-related potential. Subjects with FES had fewer episodes of anterior to posterior waves in the 2-4 Hz band compared to controls. Within the FES group, a tendency for fewer episodes of anterior to posterior waves was associated with high Psychomotor Poverty symptom factor scores.<h4>Conclusions</h4>Subjects with FES had altered global EEG dynamics along the anterior-posterior axis during task conditions involving context update.<h4>Significance</h4>The directional nature of this finding and its association with Psychomotor Poverty suggest this result is related to findings of hypofrontality in schizophrenia.-
dc.description.statementofresponsibilityDavid M. Alexander, Gary J. Flynn, Wilson Wong, Thomas J. Whitford, Anthony W.F. Harris, Cherrie A. Galletly and Steven M. Silverstein-
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/601528/description#description-
dc.language.isoen-
dc.publisherElsevier Sci Ireland Ltd-
dc.rightsCrown Copyright Copyright 2009 Published by Elsevier Ireland Ltd. on behalf of International Federation of Clinical Neurobiology. All rights reserved.-
dc.source.urihttp://dx.doi.org/10.1016/j.clinph.2009.06.020-
dc.subjectSchizophrenia-
dc.subjectEEG dynamics-
dc.subjectP3b ERP-
dc.subjectPsychomotor Poverty-
dc.subjectHypofrontality-
dc.titleSpatio-temporal EEG waves in first episode schizophrenia-
dc.typeJournal article-
dc.identifier.doi10.1016/j.clinph.2009.06.020-
pubs.publication-statusPublished-
dc.identifier.orcidGalletly, C. [0000-0001-6185-9677]-
Appears in Collections:Aurora harvest
Psychiatry publications

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