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|Title:||Spatio-temporal EEG waves in first episode schizophrenia|
|Citation:||Clinical Neurophysiology, 2009; 120(9):1667-1682|
|Publisher:||Elsevier Sci Ireland Ltd|
|David M. Alexander, Gary J. Flynn, Wilson Wong, Thomas J. Whitford, Anthony W.F. Harris, Cherrie A. Galletly and Steven M. Silverstein|
|Abstract:||OBJECTIVE: Schizophrenia is characterized by a deficit in context processing, with physiological correlates of hypofrontality and reduced amplitude P3b event-related potentials. We hypothesized an additional physiological correlate: differences in the spatio-temporal dynamics of cortical activity along the anterior-posterior axis of the scalp. METHODS: This study assessed latency topographies of spatio-temporal waves under task conditions that elicit the P3b. EEG was recorded during separate auditory and visual tasks. Event-related spatio-temporal waves were quantified from scalp EEG of subjects with first episode schizophrenia (FES) and matched controls. RESULTS: The P3b-related task conditions elicited a peak in spatio-temporal waves in the delta band at a similar latency to the P3b event-related potential. Subjects with FES had fewer episodes of anterior to posterior waves in the 2-4 Hz band compared to controls. Within the FES group, a tendency for fewer episodes of anterior to posterior waves was associated with high Psychomotor Poverty symptom factor scores. CONCLUSIONS: Subjects with FES had altered global EEG dynamics along the anterior-posterior axis during task conditions involving context update. SIGNIFICANCE: The directional nature of this finding and its association with Psychomotor Poverty suggest this result is related to findings of hypofrontality in schizophrenia.|
|Keywords:||Schizophrenia; EEG dynamics; P3b ERP; Psychomotor Poverty; Hypofrontality|
|Rights:||Crown Copyright Copyright 2009 Published by Elsevier Ireland Ltd. on behalf of International Federation of Clinical Neurobiology. All rights reserved.|
|Appears in Collections:||Psychiatry publications|
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