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Type: Journal article
Title: 3-Amino-2-hydroxy-N-(4-nitrophenyl)-propanesulphonamide, a new class of GABAB receptor antagonist in central and peripheral preparations
Author: Kerr, D.
Ong, J.
Hughes, R.
Prager, R.
Citation: Behavioural Processes, 1995; 294(1):349-352
Publisher: North Holland
Issue Date: 1995
ISSN: 0014-2999
Abstract: Racemic 3-amino-2-hydroxy-N-(4-nitrophenyl)-propanesulphonamide (AHPNS), a sulphonamide analog of GABA, reversibly and competitively antagonised the concentration-dependent depression of cholinergic twitch contractions by baclofen, in the electrically stimulated guinea-pig isolated ileum, with a pA2 of 4.0 +/- 0.2. In the rat neocortex, maintained in Mg(2+)-free medium, AHPNS (100-500 microM) also reversibly antagonised the baclofen (10 microM)-induced suppression of spontaneous discharges. AHPNS is a new class of GABAB receptor antagonist that has central and peripheral blocking actions.
Keywords: Muscle, Smooth
Central Nervous System
Cerebral Cortex
Peripheral Nervous System
Parasympathetic Nervous System
Guinea Pigs
Rats, Sprague-Dawley
GABA Agonists
Electric Stimulation
Muscle Contraction
GABA-B Receptor Agonists
GABA-B Receptor Antagonists
In Vitro Techniques
DOI: 10.1016/0014-2999(95)00688-5
Appears in Collections:Anaesthesia and Intensive Care publications
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