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https://hdl.handle.net/2440/56804
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DC Field | Value | Language |
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dc.contributor.author | Avlund, M. | - |
dc.contributor.author | Dodd, I. | - |
dc.contributor.author | Semsey, S. | - |
dc.contributor.author | Sneppen, K. | - |
dc.contributor.author | Krishna, S. | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Journal of Virology, 2009; 83(22):11416-11420 | - |
dc.identifier.issn | 0022-538X | - |
dc.identifier.issn | 1098-5514 | - |
dc.identifier.uri | http://hdl.handle.net/2440/56804 | - |
dc.description | Copyright © 2009, American Society for Microbiology. All Rights Reserved. | - |
dc.description.abstract | Phage lambda is among the simplest organisms that make a developmental decision. An infected bacterium goes either into the lytic state, where the phage particles rapidly replicate and eventually lyse the cell, or into a lysogenic state, where the phage goes dormant and replicates along with the cell. Experimental observations by P. Kourilsky are consistent with a single phage infection deterministically choosing lysis and double infection resulting in a stochastic choice. We argue that the phage are playing a "game" of minimizing the chance of extinction and that the shift from determinism to stochasticity is due to a shift from a single-player to a multiplayer game. Crucial to the argument is the clonal identity of the phage. | - |
dc.description.statementofresponsibility | Mikkel Avlund, Ian B. Dodd, Szabolcs Semsey, Kim Sneppen, and Sandeep Krishna | - |
dc.language.iso | en | - |
dc.publisher | Amer Soc Microbiology | - |
dc.source.uri | http://dx.doi.org/10.1128/jvi.01057-09 | - |
dc.subject | Bacteriophage lambda | - |
dc.subject | Probability | - |
dc.subject | Stochastic Processes | - |
dc.subject | Lysogeny | - |
dc.subject | Virus Activation | - |
dc.subject | Game Theory | - |
dc.title | Why do phage play dice? | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1128/JVI.01057-09 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Dodd, I. [0000-0003-2969-6841] | - |
Appears in Collections: | Aurora harvest Biochemistry publications |
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