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|Title:||Why do phage play dice?|
|Citation:||Journal of Virology, 2009; 83(22):11416-11420|
|Publisher:||Amer Soc Microbiology|
|Mikkel Avlund, Ian B. Dodd, Szabolcs Semsey, Kim Sneppen, and Sandeep Krishna|
|Abstract:||Phage lambda is among the simplest organisms that make a developmental decision. An infected bacterium goes either into the lytic state, where the phage particles rapidly replicate and eventually lyse the cell, or into a lysogenic state, where the phage goes dormant and replicates along with the cell. Experimental observations by P. Kourilsky are consistent with a single phage infection deterministically choosing lysis and double infection resulting in a stochastic choice. We argue that the phage are playing a "game" of minimizing the chance of extinction and that the shift from determinism to stochasticity is due to a shift from a single-player to a multiplayer game. Crucial to the argument is the clonal identity of the phage.|
|Keywords:||Bacteriophage lambda; Probability; Stochastic Processes; Lysogeny; Virus Activation; Game Theory|
|Description:||Copyright © 2009, American Society for Microbiology. All Rights Reserved.|
|Appears in Collections:||Biochemistry publications|
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