Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/55621
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Type: | Journal article |
Title: | Phase II study of capecitabine and mitomycin C as first-line treatment in patients with advanced colorectal cancer |
Author: | Rao, S. Cunningham, D. Price, T. Hill, M. Ross, P. Tebbutt, N. Norman, A. Oates, J. Shellito, P. |
Citation: | British Journal of Cancer, 2004; 91(5):839-843 |
Publisher: | Nature Publishing Group |
Issue Date: | 2004 |
ISSN: | 0007-0920 1532-1827 |
Statement of Responsibility: | S Rao, D Cunningham, T Price, M E Hill, P J Ross, N Tebbutt, A R Norman, J Oates and P Shellito |
Abstract: | This study was designed to assess the safety and efficacy of capecitabine and mitomycin C (MMC) in previously untreated patients with advanced colorectal cancer (CRC). Patients received capecitabine 2500 mg m2 day 1, orally divided in two doses of 1250 mg m-2 in the morning and evening for 14 days every 21 days and MMC 7 mg m-2 (maximum total dose 14 mg) as an intravenous bolus every 6 weeks for a total of four courses. The median age was 70 years (range 24–85) and the majority of patients (86.9%) were of performance status 1/2. The most common metastatic site was liver. In all, 84 patients were assessable for response. The overall response rate was 38% (95% CI: 27.7–49.3) and a further 33.3% of patients achieved stable disease over 12 weeks. There was good symptom resolution ranging from 64 to 86%. Grade 3/4 toxicity was as follows: hand–foot syndrome 19.7%; diarrhoea 10%; neutropenia 2.4%; infection 2.3%. Capecitabine and MMC have shown encouraging activity with a favourable toxicity profile, a convenient administration schedule, and could be considered for patients deemed unsuitable for oxaliplatin and irinotecan combinations. |
Keywords: | colorectal cancer advanced chemotherapy capecitabine mitomycin C |
Rights: | © 2004 Cancer Research UK |
DOI: | 10.1038/sj.bjc.6602039 |
Published version: | http://dx.doi.org/10.1038/sj.bjc.6602039 |
Appears in Collections: | Aurora harvest 5 Medicine publications |
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hdl_55621.pdf | Published version | 101.56 kB | Adobe PDF | View/Open |
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