Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/55391
Type: Journal article
Title: The role of lamotrigine in the management of bipolar disorders
Author: Ng, F.
Hallam, K.
Lucas, N.
Berk, M.
Citation: Neuropsychiatric Disease and Treatment, 2007; 3(4):463-474
Publisher: Dove Medical Press Ltd.
Issue Date: 2007
ISSN: 1176-6328
Statement of
Responsibility: 
Felicity Ng, Karen Hallam, Nellie Lucas, and Michael Berk
Abstract: Lamotrigine has emerged with a distinct place in the pharmacological treatment of bipolar disorder, with the potential to treat and prevent bipolar depression, which is the dominant and arguably most disabling and under-treated phase of the illness. This review examines the published clinical trials of lamotrigine in bipolar treatment. While the data supports its tolerability and safety, the strongest evidence for its efficacy lies in the prevention of bipolar depression, with weaker evidence for the treatment of acute bipolar depression, refractory unipolar and bipolar depression, and rapid cycling bipolar disorder. The total number of published well designed trials is small, even the maintenance evidence is derived from two studies. However, this relative inadequacy compares favorably with the alternative treatment options for bipolar depression, which are marked by poor efficacy or risk of polarity switch. The designation of lamotrigine as first-line treatment for bipolar depression prophylaxis should be done in cognizance of this context, and it would seem prudent to await greater evidence of efficacy before designating lamotrigine as first-line treatment for other bipolar indications. Further randomized controlled trials are required to consolidate the available findings and to explore the boundaries of lamotrigine's efficacy, which may encompass the soft spectral disorders. © 2007 Dove Medical Press Limited. All rights reserved.
Keywords: Lamotrigine
bipolar disorder
bipolar depression
clinical trials
efficacy
Description: Copyright © 2007 Dove Medical Press Limited. All rights reserved
Published version: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655087/
Appears in Collections:Aurora harvest 5
Psychiatry publications

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