Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/53339
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Type: Journal article
Title: Trastuzumab induces gastrointestinal side effects in HER2-overexpressing breast cancer patients
Author: Al-Dasooqi, N.
Bowen, J.
Gibson, R.
Sullivan, T.
Lees, J.
Keefe, D.
Citation: Investigational New Drugs, 2009; 27(2):173-178
Publisher: Kluwer Academic Publ
Issue Date: 2009
ISSN: 0167-6997
1573-0646
Statement of
Responsibility: 
Noor Al-Dasooqi, Joanne M. Bowen, Rachel J. Gibson, Thomas Sullivan, Jude Lees and Dorothy M. Keefe
Abstract: Purpose: To characterise the gastrointestinal toxicities associated with Trastuzumab administration in HER2-overexpressing breast cancer patients. Methods: All patients (n = 46) who received Trastuzumab as a single agent or in conjunction with conventional anti-cancer treatment within the Royal Adelaide Hospital Cancer Centre from 2002–2007 were included in this study. A retrospective analysis of case-notes was conducted to investigate the toxicities associated with Trastuzumab. Results: Trastuzumab as a single agent induced toxicities following 22% of administrations. Gastrointestinal toxicities were observed following 12% of administrations and included nausea and vomiting, diarrhoea, abdominal pain and bloating. However, other prominent toxicities that were not related to the gastrointestinal tract were also observed including fatigue and lung symptoms (10.4%). Elderly patients (≥60 years) and those with metastatic disease experienced the highest frequency of toxicity. Conclusion: Trastuzumab induces a range of gastrointestinal toxicities in HER2-overexpressing breast cancer patients. These toxicities are separate to those caused by concurrent chemotherapy and/or radiotherapy.
Keywords: HER2-overexpressing breast cancer
Targeted therapy
Trastuzumab
Gastrointestinal tract
Toxicity
Description: The original publication can be found at www.springerlink.com
DOI: 10.1007/s10637-008-9152-1
Published version: http://dx.doi.org/10.1007/s10637-008-9152-1
Appears in Collections:Anatomical Sciences publications
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