Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/52305
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Type: Journal article
Title: Expression of a B-cell-restricted isoform of CD45 is associated with maturity in rat serosal and connective-tissue mast cells
Author: Yu, C.
Moghaddami, M.
Mayrhofer, G.
Citation: Immunology, 2008; 125(4):558-569
Publisher: Blackwell Publishing Ltd
Issue Date: 2008
ISSN: 0019-2805
1365-2567
Statement of
Responsibility: 
Chunping Yu, Mahin Moghaddami and Graham Mayrhofer
Abstract: Fas-associated protein with death domain/mediator of receptor induced toxicity (FADD/MORT1) was first described as a transducer of death receptor signalling but was later recognized also to be important for proliferation of T cells. B-cell lymphoma 3 (Bcl-3) is a relatively little understood member of the nuclear factor (NF)-kappaB family of transcription factors. We recently found that Bcl-3 is up-regulated in T cells from mice where FADD function is blocked by a dominant negative transgene (FADD-DN). To understand the importance of this, we generated FADD-DN/bcl-3(-/-) mice. Here, we report that T cells from these mice show massive cell death and severely reduced proliferation in response to T-cell receptor (TCR) stimulation in vitro. Transgenic coexpression of Bcl-2 (FADD-DN/bcl-3(-/-)/vav-bcl-2 mice) rescued the survival but not the proliferation of T cells. FADD-DN/bcl-3(-/-) mice had normal thymocyte numbers but reduced numbers of peripheral T cells despite an increase in cycling T cells in vivo. However, activation of the classical NF-kappaB and extracellular regulated kinase (ERK) pathways and expression of interleukin (IL)-2 mRNA upon stimulation were normal in T cells from FADD-DN/bcl-3(-/-) mice. These data suggest that FADD and Bcl-3 regulate separate pathways that both contribute to survival and proliferation in mouse T cells.
Keywords: Alcian blue
arthritis
connective tissue
rat
Safranin O
serosal
DOI: 10.1111/j.1365-2567.2008.02930.x
Published version: http://dx.doi.org/10.1111/j.1365-2567.2008.02930.x
Appears in Collections:Aurora harvest
Microbiology and Immunology publications

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