Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/52305
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Expression of a B-cell-restricted isoform of CD45 is associated with maturity in rat serosal and connective-tissue mast cells |
Author: | Yu, C. Moghaddami, M. Mayrhofer, G. |
Citation: | Immunology, 2008; 125(4):558-569 |
Publisher: | Blackwell Publishing Ltd |
Issue Date: | 2008 |
ISSN: | 0019-2805 1365-2567 |
Statement of Responsibility: | Chunping Yu, Mahin Moghaddami and Graham Mayrhofer |
Abstract: | Fas-associated protein with death domain/mediator of receptor induced toxicity (FADD/MORT1) was first described as a transducer of death receptor signalling but was later recognized also to be important for proliferation of T cells. B-cell lymphoma 3 (Bcl-3) is a relatively little understood member of the nuclear factor (NF)-kappaB family of transcription factors. We recently found that Bcl-3 is up-regulated in T cells from mice where FADD function is blocked by a dominant negative transgene (FADD-DN). To understand the importance of this, we generated FADD-DN/bcl-3(-/-) mice. Here, we report that T cells from these mice show massive cell death and severely reduced proliferation in response to T-cell receptor (TCR) stimulation in vitro. Transgenic coexpression of Bcl-2 (FADD-DN/bcl-3(-/-)/vav-bcl-2 mice) rescued the survival but not the proliferation of T cells. FADD-DN/bcl-3(-/-) mice had normal thymocyte numbers but reduced numbers of peripheral T cells despite an increase in cycling T cells in vivo. However, activation of the classical NF-kappaB and extracellular regulated kinase (ERK) pathways and expression of interleukin (IL)-2 mRNA upon stimulation were normal in T cells from FADD-DN/bcl-3(-/-) mice. These data suggest that FADD and Bcl-3 regulate separate pathways that both contribute to survival and proliferation in mouse T cells. |
Keywords: | Alcian blue arthritis connective tissue rat Safranin O serosal |
DOI: | 10.1111/j.1365-2567.2008.02930.x |
Published version: | http://dx.doi.org/10.1111/j.1365-2567.2008.02930.x |
Appears in Collections: | Aurora harvest Microbiology and Immunology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.