Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/51876
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Type: Journal article
Title: Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis
Author: Jastroch, M.
Withers, K.
Taudien, S.
Frappell, P.
Helwig, M.
Fromme, T.
Hirschberg, V.
Heldmaier, G.
McAllan, B.
Firth, B.
Burmester, T.
Platzer, M.
Klingenspor, M.
Citation: Physiological Genomics, 2008; 32(2):161-169
Publisher: Amer Physiological Soc
Issue Date: 2008
ISSN: 1094-8341
1531-2267
Statement of
Responsibility: 
M. Jastroch, K. W. Withers, S. Taudien, P. B. Frappell, M. Helwig, T. Fromme, V. Hirschberg, G. Heldmaier, B. M. McAllan, B. T. Firth, T. Burmester, M. Platzer and M. Klingenspor
Abstract: Brown adipose tissue expressing uncoupling protein 1 (UCP1) is responsible for adaptive nonshivering thermogenesis giving eutherian mammals crucial advantage to survive the cold. The emergence of this thermogenic organ during mammalian evolution remained unknown as the identification of UCP1 in marsupials failed so far. Here, we unequivocally identify the marsupial UCP1 ortholog in a genomic library of Monodelphis domestica. In South American and Australian marsupials, UCP1 is exclusively expressed in distinct adipose tissue sites and appears to be recruited by cold exposure in the smallest species under investigation (Sminthopsis crassicaudata). Our data suggest that an archetypal brown adipose tissue was present at least 150 million yr ago allowing early mammals to produce endogenous heat in the cold, without dependence on shivering and locomotor activity.
Keywords: marsupials; brown adipose tissue; cold acclimation
RMID: 0020081071
DOI: 10.1152/physiolgenomics.00183.2007
Appears in Collections:Anatomical Sciences publications

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