Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/51050
Citations
Scopus Web of ScienceĀ® Altmetric
?
?
Type: Journal article
Title: Comparative effects of intraduodenal infusions of lauric and oleic acids on antropyloroduodenal motility, plasma cholecystokinin and peptide YY, appetite, and energy intake in healthy men
Author: Feltrin, K.
Little, T.
Meyer, J.
Horowitz, M.
Rades, T.
Wishart, J.
Feinle-Bisset, C.
Citation: American Journal of Clinical Nutrition, 2008; 87(5):1181-1187
Publisher: Amer Soc Clinical Nutrition
Issue Date: 2008
ISSN: 0002-9165
1938-3207
Statement of
Responsibility: 
Kate L. Feltrin, Tanya J. Little, James H. Meyer, Michael Horowitz, Thomas Rades, Judith Wishart, and Christine Feinle-Bisset
Abstract: <h4>Background</h4>The regulation of gastrointestinal function and energy intake by fatty acids depends on their chain length. Animal studies suggest that lauric acid (C12) may have more potent suppressive effects on energy intake than does oleic acid (C18).<h4>Objective</h4>We compared the effects of equicaloric loads of C12 and C18 on antropyloroduodenal (APD) motility, plasma concentrations of cholecystokinin (CCK) and peptide YY (PYY), appetite, and energy intake.<h4>Design</h4>Thirteen healthy men (aged 20-46 y) were studied on 3 occasions in double-blind, randomized fashion. APD pressure waves, plasma hormones, and appetite perceptions were measured during 60-min intraduodenal infusions of 1) C12, 2) C18, or 3) 0.9% saline as control (rate: 4 mL/min; energy load for C12 and C18: 0.4 kcal/min); between 60 and 90 min, the subjects consumed a meal. Energy intake at a buffet meal was quantified.<h4>Results</h4>C12 and C18 both reduced antral (P < 0.001) and duodenal (P < 0.01) pressure waves and stimulated isolated pyloric pressure waves (P < 0.01) and plasma CCK (P < 0.001), with no differences between them. Although C12 and C18 both increased basal pyloric pressure (P < 0.05), C12 had a greater effect than did C18 (P < 0.01). In contrast, although both C12 and C18 increased plasma PYY (P < 0.001), C18 had a greater effect than C12. C12, but not C18, suppressed energy intake (P < 0.05).<h4>Conclusions</h4>At the load administered, C12, but not C18, suppressed energy intake, and C12 was a more potent stimulant of basal pyloric pressure. These discrepant effects are not apparently accounted for by changes in CCK or PYY secretion.
Keywords: Duodenum
Pylorus
Humans
Cholecystokinin
Peptide YY
Oleic Acids
Lauric Acids
Infusions, Parenteral
Cross-Over Studies
Double-Blind Method
Appetite
Energy Intake
Gastrointestinal Motility
Pressure
Adult
Middle Aged
Male
DOI: 10.1093/ajcn/87.5.1181
Published version: http://dx.doi.org/10.1093/ajcn/87.5.1181
Appears in Collections:Aurora harvest 5
Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.