Adelaide Research & Scholarship
Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/49617
| Citations | ||
| Scopus | Web of Science® | Altmetric |
|---|---|---|
|
?
|
?
|
|
| Type: | Journal article |
| Title: | Design, Synthesis, and Structural Studies on Potent Biaryl Inhibitors of Type II Dehydroquinases |
| Author: | Payne, R. Riboldi-Tunnicliffe, A. Kerbarh, O. Abell, A. Lapthorn, A. Abell, C. |
| Citation: | ChemMedChem: chemistry enabling drug discovery, 2007; 2(7):1010-1013 |
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA |
| Issue Date: | 2007 |
| ISSN: | 1860-7179 1860-7187 |
| Abstract: | Filling the pocket: Biaryl inhibitors of type II dehydroquinase are described, designed to bind to both the active site and a subsidiary pocket. Compounds exhibited nanomolar inhibition of the enzyme, which is rationalised by molecular docking and protein crystallographic studies. (Figure Presented) © 2007 Wiley-VCH Verlag GmbH & Co. KGaA. |
| Keywords: | Antibacterials cross-coupling dehydroquinase enzyme inhibition molecular modeling |
| DOI: | 10.1002/cmdc.200700062 |
| Published version: | http://dx.doi.org/10.1002/cmdc.200700062 |
| Appears in Collections: | Aurora harvest Chemistry and Physics publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.