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Type: Journal article
Title: Gene expression in sheep skin and wool (hair)
Author: Adelson, D.
Cam, G.
DeSilva, U.
Franklin, I.
Citation: Genomics, 2004; 83(1):95-105
Publisher: Academic Press Inc Elsevier Science
Issue Date: 2004
ISSN: 0888-7543
Abstract: We sequenced 2939 ESTs from fetal and adult sheep skin. Stages of gestation were picked to coincide with the major events in skin appendage (wool follicle) formation. Clustering analysis generated a nonredundant set of ESTs 2435 strong (83% nonredundant). Approximately 24% of these gave no hit to NCBI build 29 of the human genome, while 35% were tentatively classified by putative function based on BLASTX hits with a p(N) of <10⁻⁴. In addition to bioinformatics analysis of our ESTs and gene mapping, we have generated a large EST spatial expression data set using in situ hybridization. One thousand one hundred forty-two ESTs have been used for in situ localization; about 31% are from adult sheep skin, 39% from late gestation fetal sheep skin, and 30% from midgestation fetal sheep skin. These probes have been used in over 3000 hybridization experiments. In this report, we summarize the results of in situs on adult sheep skin.
Keywords: wool follicle
DOI: 10.1016/S0888-7543(03)00210-6
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Appears in Collections:Aurora harvest 6
Environment Institute publications
Molecular and Biomedical Science publications

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