Adelaide Research & Scholarship
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https://hdl.handle.net/2440/45610
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| Type: | Journal article |
| Title: | Bacterial degradation of microcystin toxins in drinking water eliminates their toxicity |
| Author: | Ho, L. Gaudieux, A. Fanok, S. Newcombe, G. Humpage, A. |
| Citation: | Toxicon, 2007; 50(3):438-441 |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Issue Date: | 2007 |
| ISSN: | 0041-0101 1879-3150 |
| Statement of Responsibility: | Lionel Ho, Anne-Laure Gaudieux, Stella Fanok, Gayle Newcombe and Andrew R. Humpage |
| Abstract: | Microcystin-LR and -LA were readily biodegraded by a bacterium, Sphingpoyxis sp. LH21, in a treated reservoir water. Detection of the microcystins was conducted using high-performance liquid chromatography (HPLC), protein phosphatase 2A (PP2A) inhibition assay and a cell-based cytotoxicity assay. The HPLC results correlated well with the two assays. The decrease in cytotoxicity, coupled with the associated decrease in microcystin concentrations, indicated that no cytotoxic by-products were being generated, highlighting the applicability of biodegradation as a feasible treatment option for effective microcystin removal. |
| Keywords: | Vero Cells Animals Alphaproteobacteria Water Biodegradation, Environmental Microcystins Chlorocebus aethiops |
| Description: | Copyright © 2007 Elsevier Ltd All rights reserved. |
| DOI: | 10.1016/j.toxicon.2007.03.021 |
| Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/259/description#description |
| Published version: | http://dx.doi.org/10.1016/j.toxicon.2007.03.021 |
| Appears in Collections: | Aurora harvest 6 Environment Institute publications Pharmacology publications |
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