Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/39955
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Type: Journal article
Title: 25-Hydroxyvitamin D requirement for maintaining skeletal health utilising a Sprague-Dawley rat model
Author: Anderson, P.
Sawyer, A.
May, B.
O'Loughlin, P.
Morris, H.
Citation: The Journal of Steroid Biochemistry and Molecular Biology, 2007; 103(3-5 Sp Iss):592-595
Publisher: Pergamon-Elsevier Science Ltd
Issue Date: 2007
ISSN: 0960-0760
1879-1220
Statement of
Responsibility: 
P.H. Anderson, R.K. Sawyer, B.K. May, P.D. O’Loughlin and H.A. Morris
Abstract: To study the role of vitamin D to optimise bone architecture, we have developed an animal model to investigate the effects of frank vitamin D-deficiency as well as graded depletion of circulating 25-hydroxyvitamin D₃ (25D) levels on the skeleton. Rats fed on dietary vitamin D levels from 0 to 500 ng/day achieved diet-dependent circulating levels of 25D ranging from 11 to 115 nmol/L. Levels of serum 1,25-dihydroxyvitamin D₃ (1,25D) increased as dietary vitamin D increased between 0 and 200 ng/day at which point a maximum level was achieved and retained with higher vitamin D intakes. The renal levels of 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) mRNA were highest in animal groups fed on vitamin D between 0 and 300 ng/day. In contrast, renal 25-hydroxyvitamin D 24-hydroxylase (CYP24) mRNA levels increased as dietary vitamin D increased achieving maximum levels in animals receiving 500 ng vitamin D/day. This animal model of vitamin D depletion is suitable to provide invaluable information on the serum levels of 25D and dietary calcium intake necessary for optimal bone structure. Such information is essential for developing nutritional recommendations to reduce the incidence of osteoporotic hip fractures.
Keywords: Vitamin D-deficiency
Kidney
Osteomalacia
Osteoporosis
25-Hydroxyvitamin D-1α-hydroxylase
25-Hydroxyvitamin D-24 hydroxylase
Description: Special Issue: Proceedings of the 13th Workshop on Vitamin D (Victoria, British Columbia, Canada, April 2006). Edited by R. Bouillon, A.W. Norman and J.R. Pasqualini Copyright © 2007 Elsevier Ltd All rights reserved.
DOI: 10.1016/j.jsbmb.2006.12.086
Description (link): http://www.elsevier.com/wps/find/journaldescription.cws_home/333/description#description
Published version: http://dx.doi.org/10.1016/j.jsbmb.2006.12.086
Appears in Collections:Aurora harvest
Molecular and Biomedical Science publications

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