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dc.contributor.authorTalley, N.en
dc.contributor.authorYoung, L.en
dc.contributor.authorBytzer, P.en
dc.contributor.authorHammer, J.en
dc.contributor.authorLeemon, M.en
dc.contributor.authorJones, M.en
dc.contributor.authorHorowitz, M.en
dc.identifier.citationAmerican Journal of Gastroenterology, 2001; 96(1):71-76en
dc.descriptionThe definitive version is available at www.blackwell-synergy.comen
dc.description.abstractOBJECTIVES: Morbidity from GI symptoms in diabetes is considered to be high, but no studies have quantified the impact of GI symptoms in diabetes on health-related quality of life. We hypothesized that diabetics reporting increased GI symptoms would experience more impaired quality of life. METHODS: Subjects from the community with diabetes (n = 892) and outpatients with diabetes (n = 209) were recruited for this study. Subjects were divided into type 1 (diabetes diagnosed at age <30 yr and requiring insulin) and type 2. A validated questionnaire measuring GI symptoms and diabetes status and the Short Form-36 were completed. The results were compared with Australian normal data. GI symptom groups measured were frequent abdominal pain, bowel-related abdominal pain, reflux, dyspepsia, constipation, diarrhea, and fecal incontinence. RESULTS: There was a clinically significant decrease in quality-of-life scores in diabetics compared with population norms across all subscales. The impact on quality of life in diabetes was predominantly observed in type 2 diabetics. The quality-of-life scores in all subscales decreased markedly with increasing numbers of distinct GI symptom groups, and this was similar in community and outpatient diabetics. For all the Short Form-36 subscales, GI symptom groups were significantly (all p < 0.0001) associated with poorer quality of life in diabetes, independent of age, gender, smoking, alcohol use, and type of diabetes. CONCLUSIONS: GI symptoms impact negatively on health-related quality of life in diabetes mellitus.en
dc.description.statementofresponsibilityNicholas J. Talley, Lisa Young, Peter Bytzer, Johann Hammer, Melanie Leemon, Michael Jones, and Michael Horowitzen
dc.publisherBlackwell Publishing Ltden
dc.rights© 2001 The American College of Gastroenterologyen
dc.subjectHumans; Gastrointestinal Diseases; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Chronic Disease; Health Surveys; Questionnaires; Prevalence; Analysis of Variance; Probability; Risk Factors; Comorbidity; Age Distribution; Sex Distribution; Quality of Life; Adult; Aged; Middle Aged; Female; Maleen
dc.titleImpact of chronic gastrointestinal symptoms in diabetes mellitus on health-related quality of lifeen
dc.typeJournal articleen
pubs.library.collectionMedicine publicationsen
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
Appears in Collections:Medicine publications

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