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Type: Journal article
Title: Zebrafish Angiotensin II receptor-like 1a (agtrl1a) is expressed in migrating hypoblast, vasculature, and in multiple embryonic epithelia
Author: Tucker, B.
Hepperle, C.
Kortschak, R.
Rainbird, B.
Wells, S.
Oates, A.
Lardelli, M.
Citation: Gene Expression Patterns, 2007; 7(3):258-265
Publisher: Elsevier BP
Issue Date: 2007
ISSN: 1567-133X
Organisation: Centre for the Molecular Genetics of Development
Statement of
B. Tucker, C. Hepperle, D. Kortschak, B. Rainbird, S. Wells, A.C. Oates and M. Lardelli
Abstract: The human gene AGTRL1 is an angiotensin II receptor-like gene expressed in vasculature, which acts as the receptor for the small peptide APELIN, and a co-receptor for Human Immunodeficiency Virus. Mammalian AGTRL1 has been shown to modulate cardiac contractility, venous and arterial dilation, and endothelial cell migration in vitro, but no role in the development of the vasculature, or other tissues, has been described. We report the identification and expression of the zebrafish ortholog of the human gene AGTRL1. Zebrafish agtrl1a is first expressed before epiboly in dorsal precursors. During epiboly it is expressed in the enveloping layer, yolk syncytial layer and migrating mesendoderm. During segmentation stages, expression is observed in epithelial structures such as adaxial cells, border cells of the newly formed somites, developing lens, otic vesicles and venous vasculature.
Keywords: Zebrafish
G protein-coupled receptor
Angiotensin receptor
Description: Copyright © 2006 Elsevier B.V. All rights reserved.
DOI: 10.1016/j.modgep.2006.09.006
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Appears in Collections:Aurora harvest
Centre for the Molecular Genetics of Development publications
Molecular and Biomedical Science publications

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