Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/30869
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Type: Book chapter
Title: Wear and Osteolysis in relation to Prostheses Design and Materials
Author: Howie, D.
McGee, M.
Citation: Medical Applications of Titanium and Its Alloys: The Material and Biological Issues, 1996, vol.1272, pp.388-398
Publisher: American Society for Testing and Materials
Issue Date: 1996
ISBN: 9780803120105
Abstract: A major concern in joint replacement surgery is periprosthetic osteolysis which leads to aseptic loosening of prosthetic implants. Radiographic studies and implant retrieval analysis have been used to establish the relationship between excessive wear of different implant designs and implant failure. The potential sources of wear particles can be divided into articulating and non-articulating interfaces of joint replacement prostheses. Laboratory techniques can be used to produce wear particles of the size and shape similar to that seen around prostheses. In-vitro and in-vivo studies are useful in defining the mechanisms whereby wear particles may induce a cellular response which causes bone resorption and loosening.
DOI: 10.1520/stp16093s
Appears in Collections:Aurora harvest 6
Orthopaedics and Trauma publications

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