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https://hdl.handle.net/2440/3048
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Type: | Journal article |
Title: | Impaired clearance of herpes simplex virus type 1 from mice lacking CD1d or NKT cells expressing the semivariant Vα14-Jα 281 TCR |
Other Titles: | Impaired clearance of herpes simplex virus type 1 from mice lacking CD1d or NKT cells expressing the semivariant Valpha14-Jalpha 281 TCR |
Author: | Grubor-Bauk, B. Simmons, A. Mayrhofer, G. Speck, P. |
Citation: | Journal of Immunology, 2003; 170(3):1430-1434 |
Publisher: | Amer Assoc Immunologists |
Issue Date: | 2003 |
ISSN: | 0022-1767 1550-6606 |
Statement of Responsibility: | Branka Grubor-Bauk, Anthony Simmons, Graham Mayrhofer and Peter G. Speck |
Abstract: | Ag-presenting molecule CD1 and CD1-restricted NKT cells are known to contribute to defense against a range of infectious pathogens, including some viruses. CD1-restricted NKT cells, a distinct subpopulation of T cells, have striking and rapid effector functions that contribute to host defense, including rapid production of IFN-y and IL-4, and activation of NK cells. Consideration of the important contributions of innate and adaptive immunity to clearance of HSV prompted us to investigate the role of CD1 and of NKT cells expressing the Vα14-Jα281 TCR in the pathogenesis of HSV infection. To address this issue, we compared infection in wild-type mice with that in CD1 gene knockout (GKO) and Jα281 GKO mice. In this study, we report impaired clearance of virus and viral Ags, and more florid acute infection in mice lacking CD1 (and by inference, CD1-restricted T cells), in comparison with parental C57BL6 mice. In Jα281 GKO mice there was also impairment of virus clearance, resembling that seen in CD1 GKO mice. These results imply roles for the Vα14-Jα281 subset of NKT cells and for CD1d in control of HSV infection. |
Keywords: | Ganglia, Sensory Killer Cells, Natural T-Lymphocyte Subsets Animals Mice, Inbred C57BL Mice, Knockout Mice Herpesvirus 1, Human Herpes Simplex Receptors, Antigen, T-Cell, alpha-beta Protein Isoforms Antigens, CD1 Antigens, Viral Viral Load Severity of Illness Index Virus Latency Time Factors Genetic Variation Antigens, CD1d |
Description: | Copyright © 2003 by The American Association of Immunologists |
DOI: | 10.4049/jimmunol.170.3.1430 |
Published version: | http://www.jimmunol.org/cgi/content/abstract/170/3/1430 |
Appears in Collections: | Aurora harvest 2 Molecular and Biomedical Science publications |
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