Please use this identifier to cite or link to this item:
Scopus Web of ScienceĀ® Altmetric
Type: Journal article
Title: Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary
Author: Scholpp, S.
Groth, C.
Lohs, C.
Lardelli, M.
Brand, M.
Citation: Development, Genes and Evolution, 2004; 214(6):285-295
Publisher: Springer
Issue Date: 2004
ISSN: 0949-944X
Organisation: Centre for the Molecular Genetics of Development
Statement of
Steffen Scholpp, Casper Groth, Claudia Lohs Michael Lardelli and Michael Brand
Abstract: FGFR1 is an important signalling molecule during embryogenesis and in adulthood. FGFR1 mutations in human may lead to developmental defects and pathological conditions, including cancer and Alzheimers disease. Here, we describe cloning and expression analysis of the zebrafish fibroblast growth factor receptor 1 (fgfr1). Initially, fgfr1 is expressed in the adaxial mesoderm with transcripts distinctly localised to the anterior portion of each half-somite. Hereupon, fgfr1 is also strongly expressed in the otic vesicles, branchial arches and the brain, especially at the midbrain-hindbrain boundary (MHB). The expression patterns of fgfr1 and fgf8 are strikingly similar and knock-down of fgfr1 phenocopies many aspects observed in the fgf8 mutant acerebellar, suggesting that Fgf8 exerts its function mainly by binding to FgfR1.
Keywords: Fgf8
Fibroblast growth factor receptor 1
Midbrain-hindbrain boundary
Description: The original publication can be found at
DOI: 10.1007/s00427-004-0409-1
Published version:
Appears in Collections:Aurora harvest 6
Centre for the Molecular Genetics of Development publications
Molecular and Biomedical Science publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.