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https://hdl.handle.net/2440/28127
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Type: | Journal article |
Title: | A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors |
Author: | Andersson, P. McGuire, J. Rubio, C. Gradin, K. Whitelaw, M. Pettersson, S. Hanberg, A. Poellinger, L. |
Citation: | Proceedings of the National Academy of Sciences of USA, 2002; 99(15):9990-9995 |
Publisher: | Natl Acad Sciences |
Issue Date: | 2002 |
ISSN: | 0027-8424 1091-6490 |
Organisation: | Centre for the Molecular Genetics of Development |
Statement of Responsibility: | Patrik Andersson, Jacqueline McGuire, Carlos Rubio, Katarina Gradin, Murray L. Whitelaw, Sven Pettersson, Annika Hanberg, and Lorenz Poellinger |
Abstract: | The dioxin/aryl hydrocarbon receptor (AhR) functions as a ligand-activated transcription factor regulating transcription of a battery of genes encoding xenobiotic metabolizing enzymes. Known receptor ligands are environmental pollutants including polycyclic aromatic hydrocarbons and polychlorinated dioxins. Loss-of-function (gene-disruption) studies in mice have demonstrated that the AhR is involved in toxic effects of dioxins but have not yielded unequivocal results concerning the physiological function of the receptor. Gain-of-function studies therefore were performed to unravel the biological functions of the AhR. A constitutively active AhR expressed in transgenic mice reduced the life span of the mice and induced tumors in the glandular part of the stomach, demonstrating the oncogenic potential of the AhR and implicating the receptor in regulation of cell proliferation. |
Keywords: | Liver Thymus Gland CHO Cells Animals Mice, Inbred C57BL Mice, Inbred CBA Mice Intestinal Neoplasms Stomach Neoplasms Cytochrome P-450 CYP1A1 Receptors, Aryl Hydrocarbon Recombinant Proteins Carcinogens Cloning, Molecular Transfection Gene Expression Regulation, Developmental Cricetinae Male Polychlorinated Dibenzodioxins |
Description: | Published online before print July 9, 2002 |
Rights: | Copyright © 2002 by the National Academy of Sciences |
DOI: | 10.1073/pnas.152706299 |
Published version: | http://www.pnas.org/content/99/15/9990 |
Appears in Collections: | Aurora harvest 2 Centre for the Molecular Genetics of Development publications Molecular and Biomedical Science publications |
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