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https://hdl.handle.net/2440/23411
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Type: | Journal article |
Title: | Effect of fatty acid chain length on suppression of ghrelin and stimulation of PYY, GLP-2 and PP secretion in healthy men |
Author: | Feltrin, K. Patterson, M. Ghatei, M. Bloom, S. Meyer, J. Horowitz, M. Feinle-Bisset, C. |
Citation: | Peptides, 2006; 27(7):1638-1643 |
Publisher: | Elsevier Science Inc |
Issue Date: | 2006 |
ISSN: | 0196-9781 1873-5169 |
Statement of Responsibility: | Kate L. Feltrin, Michael Patterson, Mohammad A. Ghatei, Stephen R. Bloom, James H. Meyer, Michael Horowitz, Christine Feinle-Bisset |
Abstract: | We have evaluated the effects of fatty acid chain length on ghrelin, peptide YY (PYY), glucagon-like peptide-2 (GLP-2) and pancreatic polypeptide (PP) secretion and hypothesized that intraduodenal administration of dodecanoic ("C12"), but not decanoic ("C10"), acid would decrease plasma ghrelin and increase PYY, GLP-2 and PP concentrations. Plasma hormone concentrations were measured in seven healthy men during 90-min intraduodenal infusions of: (i) C12, (ii) C10 or (iii) control (rate: 2 ml/min, 0.375 kcal/min for C12/C10) and after a buffet-meal consumed following the infusion. C12 markedly suppressed plasma ghrelin and increased both PYY and GLP-2 (all P < 0.05) compared with control and C10, while C10 had no effect. Both C10 and C12 increased PP concentrations slightly (P < 0.05). We conclude that the effects of intraduodenal fatty acids on ghrelin, PYY and GLP-2 secretion are dependent on their chain length. |
Keywords: | Duodenum Animals Humans Rats Peptide YY Pancreatic Polypeptide Peptide Hormones Fatty Acids Feeding Behavior Time Factors Adult Middle Aged Male Glucagon-Like Peptide 2 Glucagon-Like Peptides Ghrelin |
Rights: | © 2006 Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.peptides.2006.01.023 |
Published version: | http://dx.doi.org/10.1016/j.peptides.2006.01.023 |
Appears in Collections: | Aurora harvest 2 Medicine publications |
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