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|Title:||Tumour-suppressive activity of the growth arrest-specific gene, GAS1 / by Andreas Avdokiou.|
|School/Discipline:||Dept. of Physiology|
|Abstract:||The results presented in this thesis establish the growth-suppressive activity of the human GAS1 gene and provide the first direct evidence that GAS1 can inhibit the growth of tumours. In addition, this study demonstrates that the antiproliferative effect of GAS1 are mediated by a p53 dependent pathway and that functional inactivation of p53 by either mutation and/or overexpression of the MDM2 oncogene product inhibits the GAS1 mediated growth-suppression.|
|Dissertation Note:||Thesis (Ph.D.)--University of Adelaide, Dept. of Physiology, 1997?|
In situ hybridization.
|Description:||Bibliography: leaves 170-196.|
xix, 199 leaves,  leaves of plates : ill. (some col.) ; 30 cm.
|Provenance:||This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals|
|Appears in Collections:||Research Theses|
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|01front.pdf||246.47 kB||Adobe PDF||View/Open|
|02whole.pdf||13.69 MB||Adobe PDF||View/Open|
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