Please use this identifier to cite or link to this item:
|Title:||Investigating the role of ARNT isoforms as bHLH/PAS transcriptional regulators / Robyn Jane Kewley.|
|Author:||Kewley, Robyn Jane|
|School/Discipline:||Dept. of Molecular Biosciences|
|Abstract:||The aims of this thesis were to explore novel roles of ARNT as a transcriptional regulator and to investigate possible differential activities of ARNT isoforms. To investigate whether ARNT plays roles as a transcription factor additional to being a partner to known factors such as DR and HIF-a, a search for downstream target genes was planned. Hepa cell lines overexpressing a dominant negative form of ARNT and a Suppression Subtractive Hybridisation PCR approach were used. Complementing these studies was a search for differences in function between two alternatively spliced forms of ARNT, ARNT and Alt ARNT. Specifically, the author sought to determine if ARNT and Alt ARNT could be differentially phosphorylated and whether such phosphorylation could affect DNA-binding properties. --p. 105.|
|Dissertation Note:||Thesis (Ph.D.)--University of Adelaide, Dept. of Molecular Biosciences|
|Description:||Bibliography: leaves 111-127.|
xii, 127 leaves : ill. (some col.) ; 30 cm.
|Provenance:||This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals.|
|Appears in Collections:||Research Theses|
Files in This Item:
|01front.pdf||154.1 kB||Adobe PDF||View/Open|
|02whole.pdf||9.92 MB||Adobe PDF||View/Open|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.