Adelaide Research & Scholarship
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https://hdl.handle.net/2440/21909
| Type: | Thesis |
| Title: | Ethanol teratogenicity : the aetiological importance of zinc and metallothionein / by Luke Charles Carey. |
| Author: | Carey, Luke Charles |
| Issue Date: | 2002 |
| School/Discipline: | Dept. of Physiology |
| Abstract: | Changes in maternal-foetal zinc homeostasis resulting in a foetal deficiency may be an important contributing factor in ethanol-realted teratogenicity. Ethanol induces expression of hepatic metallothionein, causing zinc transfer from the plasma to the liver. Rodent studies show that changes in plasma zinc correlate with a high incidence of abnormal fetuses in MT+/+ mice. Demonstrates a clear link between maternal hepatic MT induction, decreased foetal zinc supply, and teratogenicity, which has major implications for binge alcohol consumption in early pregnancy. The demonstration that zinc treatment is effective in preventing teratogenicity indicates potential treatment strategies. |
| Dissertation Note: | Thesis (Ph.D.)--University of Adelaide, Dept. of Physiology, 2003 |
| Subject: | Fetal alcohol syndrome Animal models. Zinc in the body Animal models. Alcohol Toxicology Animal models. Metallothionein Physiological effect Animal models. |
| Description: | "August 2002" Bibliography: leaves 141-176. ix, 179 leaves : ill. (some col.) ; 30 cm |
| Provenance: | This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals |
| Appears in Collections: | Research Theses |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 01front.pdf | 69.7 kB | Adobe PDF | View/Open | |
| 02whole.pdf | 7.18 MB | Adobe PDF | View/Open |
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