Adelaide Research & Scholarship
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https://hdl.handle.net/2440/21754
| Type: | Thesis |
| Title: | Production and function of a soluble c-Kit molecule / by Stuart Hamilton Read. |
| Author: | Read, Stuart Hamilton |
| Issue Date: | 2001 |
| School/Discipline: | Dept. of Molecular Biosciences |
| Abstract: | Elevated levels of receptor tyrosine kinases have been implicated in carcinogenesis. It is possible that high expression of c-Kit by the leukaemic cell provides them with a growth advantage over their normal counterparts in the bone marrow microenvironment. Thus, a means of inhibiting the interaction of c-Kit on these cells with ligand Steel Factor may remove proliferation and survival signals. Main aim of the study was to produce a biological inhibitor of this interaction and evaluate its ability to prevent ligand Steel Factor from binding to c-Kit on live cells. |
| Dissertation Note: | Thesis (Ph.D.)--University of Adelaide, Dept. of Molecular Biosciences, 2001 |
| Subject: | Protein-tyrosine kinase. Hematopoiesis Receptor-ligand complexes |
| Description: | "Research conducted at the Department of Haematology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science."--T.p. Includes bibliographical references (leaves 170-214). xiv, 221 leaves : ill. (some col.) ; 30 cm. |
| Provenance: | This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available, or if you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals |
| Appears in Collections: | Research Theses |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 01front.pdf | 539.27 kB | Adobe PDF | View/Open | |
| 02whole.pdf | 18.43 MB | Adobe PDF | View/Open |
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