Molecular definition of stromal cell-stem cell interactions / by Andrew Christopher William Zannettino.

Abstract

The date presented in this thesis is directed toward the molecular characterisation of cell surface molecules (CSMs) that mediate interactions between human haemopoietic progenitor cells (HPC) and cells of the bone marrow (BM) stroma. The research focuses on the role of selectins in the regulation of haemopoiesis, the identification and molecular characterisation of novel structures expressed at the surface of primitive human HPC and cultured BM stromal cells, the molecular characterisation of the antigen identified by the mAb HCC-1 which delineates a subset of the CD34+ cell population, and the molecular cloning of a novel mucin-like transmembrane glycoprotein termed MGC -24v.