Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/1584
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Proteoglycan changes in carcinogen (4WQ0)-Treated tongue mucosa |
Author: | Wilson, D. Vreugdenburg, A. Wiebkin, O. |
Citation: | Journal Of Oral Pathology and Medicine, 1995; 24(3):113-117 |
Publisher: | Munksgaard, Denmark |
Issue Date: | 1995 |
ISSN: | 0904-2512 1600-0714 |
Abstract: | The purpose of this study was to undertake preliminary analyses of the extracellular proteoglycans in carcinogen [4-nitroquinoline N-oxide (4NQO)]-treated rat tongue mucosa. Experimental rats were exposed to twice-weekly applications of 4NQO in propylene glycol for six months, after which the animals were killed. Control and 4NQO-treated tissues were subjected to sequential aqueous extractions of proteoglycans under associative and dissociative conditions, followed by alkaline cleavage of protein-glycosaminoglycan linkages to yield a glycosaminoglycan residue. Tissues subjected to 4NQO applications contained smaller proportions of proteoglycans which were readily soluble under associative and dissociative conditions. Proportionately more proteoglycan remained strongly associated with other intercellular tissue components, being released only by alkaline cleavage. These biochemical alterations in preinvasive 4NQO-treated epithelium and connective tissues, together with an observed associated change in water retention by the connective tissue, occurred prior to actual neoplastic invasion and suggest differences in macromolecular conformation and orderliness. We hypothesize that these changes are related to the phenomenon of neoplastic epithelial invasion. |
Keywords: | Tongue Connective Tissue Epithelium Mouth Mucosa Body Water Animals Rats, Inbred Strains Rats Carcinoma Tongue Neoplasms Neoplasm Invasiveness Precancerous Conditions Hyperplasia 4-Nitroquinoline-1-oxide Glycosaminoglycans Proteoglycans Extracellular Matrix Proteins Administration, Topical Solubility Female |
DOI: | 10.1111/j.1600-0714.1995.tb01150.x |
Published version: | http://dx.doi.org/10.1111/j.1600-0714.1995.tb01150.x |
Appears in Collections: | Aurora harvest 2 Dentistry publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.