Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/137598
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Type: Journal article
Title: The effectiveness of anti-inflammatory agents in reducing chemotherapy-induced cognitive impairment in preclinical models – a systematic review
Author: Haller, O.J.
Semendric, I.
George, R.P.
Collins-Praino, L.E.
Whittaker, A.L.
Citation: Neuroscience and Biobehavioral Reviews, 2023; 148:105120-1-105120-37
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Issue Date: 2023
ISSN: 0149-7634
1873-7528
Statement of
Responsibility: 
Olivia J Haller, Ines Semendric, Rebecca P George, Lyndsey E Collins-Praino, Alexandra L Whittaker
Abstract: Chemotherapy-induced cognitive impairment (CICI) is a debilitating condition resulting from chemotherapy administration for cancer treatment. CICI is characterised by various cognitive impairments, including issues with learning, memory, and concentration, impacting quality of life. Several neural mechanisms are proposed to drive CICI, including inflammation, therefore, anti-inflammatory agents could ameliorate such impairments. Research is still in the preclinical stage; however, the efficacy of anti-inflammatories to reduce CICI in animal models is unknown. Therefore, a systematic review was conducted, with searches performed in PubMed, Scopus, Embase, PsycInfo and Cochrane Library. A total of 64 studies were included, and of the 50 agents identified, 41 (82%) reduced CICI. Interestingly, while nontraditional anti-inflammatory agents and natural compounds reduced impairment, the traditional agents were unsuccessful. Such results must be taken with caution due to the heterogeneity observed in terms of methods employed. Nevertheless, preliminary evidence suggests anti-inflammatory agents could be beneficial for treating CICI, although it may be critical to think beyond the use of traditional anti-inflammatories when considering which specific compounds to prioritise in development.
Keywords: chemotherapy; chemobrain; chemotherapy-induced cognitive impairment; cognitive impairment; anti-inflammatory agent; NSAID; cancer; inflammation
Description: Published May 2023
Rights: © 2023 The Author(s). Published by Elsevier Ltd. This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.
DOI: 10.1016/j.neubiorev.2023.105120
Grant ID: http://purl.org/au-research/grants/nhmrc/APP1140072
Published version: https://www.sciencedirect.com/science/article/pii/S0149763423000891
Appears in Collections:Molecular and Biomedical Science publications

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