Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/137399
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Type: | Journal article |
Title: | Clinical applications of non‐invasive multi and hyperspectral imaging of cell and tissue autofluorescence beyond oncology |
Author: | Campbell, J.M. Mahbub, S.B. Habibalahi, A. Agha, A. Handley, S. Anwer, A.G. Goldys, E.M. |
Citation: | Journal of Biophotonics, 2023; 16(4):1-14 |
Publisher: | Wiley |
Issue Date: | 2023 |
ISSN: | 1864-063X 1864-0648 |
Statement of Responsibility: | Jared M. Campbell, Saabah B. Mahbub, Abbas Habibalahi, Adnan Agha, Shannon Handley, Ayad G. Anwer, Ewa M. Goldys |
Abstract: | Hyperspectral and multispectral imaging of cell and tissue autofluorescence employs fluorescence imaging, without exogenous fluorophores, across multiple excitation/ emission combinations (spectral channels). This produces an image stack where each pixel (matched by location) contains unique information about the sample's spectral properties. Analysis of this data enables access to a rich, molecularly specific data set from a broad range of cell-native fluorophores (autofluorophores) directly reflective of biochemical status, without use of fixation or stains. This non-invasive, non-destructive technology has great potential to spare the collection of biopsies from sensitive regions. As both staining and biopsy may be impossible, or undesirable, depending on the context, this technology great diagnostic potential for clinical decision making. The main research focus has been on the identification of neoplastic tissues. However, advances have been made in diverse applications—including ophthalmology, cardiovascular health, neurology, infection, assisted reproduction technology and organ transplantation. |
Keywords: | Optical Imaging Hyperspectral Imaging |
Rights: | © 2023 The Authors. Journal of Biophotonics published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
DOI: | 10.1002/jbio.202200264 |
Grant ID: | http://purl.org/au-research/grants/arc/DP210102960 |
Published version: | http://dx.doi.org/10.1002/jbio.202200264 |
Appears in Collections: | Public Health publications |
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hdl_137399.pdf | Published version | 1.29 MB | Adobe PDF | View/Open |
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