Adelaide Research & Scholarship
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https://hdl.handle.net/2440/137002
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| Type: | Journal article |
| Title: | Efficient O-demethylation of lignin monoaromatics using the peroxygenase activity of cytochrome P450 enzymes |
| Author: | Harlington, A.C. Shearwin, K.E. Bell, S.G. Whelan, F. |
| Citation: | Chemical Communications, 2022; 58(96):13321-13324 |
| Publisher: | Royal Society of Chemistry |
| Issue Date: | 2022 |
| ISSN: | 1359-7345 1364-548X |
| Statement of Responsibility: | Alix C. Harlington, Keith E. Shearwin, Stephen G. Bell and Fiona Whelan |
| Abstract: | A crucial reaction in harnessing renewable carbon from lignin is O-demethylation. We demonstrate the selective O-demethylation of syringol and guaiacol using different cytochrome P450 enzymes. These can efficiently use hydrogen peroxide which, when compared to nicotinamide cofactor-dependent monooxygenases and synthetic methods, allows for cheap and clean O-demethylation of lignin-derived aromatics. |
| Keywords: | Hydrogen Peroxide Lignin Cytochrome P-450 Enzyme System Demethylation |
| Rights: | © The Royal Society of Chemistry 2022. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. |
| DOI: | 10.1039/d2cc04698a |
| Grant ID: | http://purl.org/au-research/grants/arc/DP200102411 |
| Published version: | http://dx.doi.org/10.1039/d2cc04698a |
| Appears in Collections: | Chemistry and Physics publications |
Files in This Item:
| File | Description | Size | Format | |
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| hdl_137002.pdf | Published version | 1.56 MB | Adobe PDF | View/Open |
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