Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential

Nefzger, C.M.; Jardé, T.; Srivastava, A.; Schroeder, J.; Rossello, F.J.; Horvay, K.; Prasko, M.; Paynter, J.M.; Chen, J.; Weng, C.-F.; Sun, Y.B.Y.; Liu, X.; Chan, E.; Deshpande, N.; Chen, X.; Li, Y.J.; Pflueger, J.; Engel, R.M.; Knaupp, A.S.; Tsyganov, K.; et al.

Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/135652

Scopus	Web of Science®	Altmetric
Citations
?	?

Type:	Journal article
Title:	Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential
Author:	Nefzger, C.M. Jardé, T. Srivastava, A. Schroeder, J. Rossello, F.J. Horvay, K. Prasko, M. Paynter, J.M. Chen, J. Weng, C.-F. Sun, Y.B.Y. Liu, X. Chan, E. Deshpande, N. Chen, X. Li, Y.J. Pflueger, J. Engel, R.M. Knaupp, A.S. Tsyganov, K. et al.
Citation:	npj Regenerative Medicine, 2022; 7(1):31-1-31-8
Publisher:	Springer Science and Business Media LLC
Issue Date:	2022
ISSN:	2057-3995 2057-3995
Statement of Responsibility:	Christian M. Nefzger, Thierry Jardé, Akanksha Srivastava, Jan Schroeder, Fernando J. Rossello, Katja Horvay, Mirsada Prasko, Jacob M. Paynter, Joseph Chen, Chen-Fang Weng, Yu B. Y. Sun, Xiaodong Liu, Eva Chan, Nikita Deshpande, Xiaoli Chen, Y. Jinhua Li, Jahnvi Pflueger, Rebekah M. Engel, Anja S. Knaupp, Kirill Tsyganov, Susan K. Nilsson, Ryan Lister, Owen J. L. Rackham, Helen E. Abud, and Jose M. Polo
Abstract:	The impact of aging on intestinal stem cells (ISCs) has not been fully elucidated. In this study, we identified widespread epigenetic and transcriptional alterations in old ISCs. Using a reprogramming algorithm, we identified a set of key transcription factors (Egr1, Irf1, FosB) that drives molecular and functional differences between old and young states. Overall, by dissecting the molecular signature of aged ISCs, our study identified transcription factors that enhance the regenerative capacity of ISCs.
Rights:	© The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons. org/licenses/by/4.0/.
DOI:	10.1038/s41536-022-00226-7
Grant ID:	http://purl.org/au-research/grants/nhmrc/1061883 http://purl.org/au-research/grants/nhmrc/1188689 http://purl.org/au-research/grants/nhmrc/1146623 http://purl.org/au-research/grants/nhmrc/1129600
Published version:	http://dx.doi.org/10.1038/s41536-022-00226-7
Appears in Collections:	Medicine publications South Australian Immunogenomics Cancer Institute (SAIGENCI) publications

Files in This Item:

File	Description	Size	Format
hdl_135652.pdf	Published version	1.82 MB	Adobe PDF	View/Open

Show full item record

Adelaide Research & Scholarship