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https://hdl.handle.net/2440/135184
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Type: | Journal article |
Title: | Circular RNAs in Pregnancy and the Placenta |
Author: | Arthurs, A.L. Jankovic-Karasoulos, T. Smith, M.D. Roberts, C.T. |
Citation: | International Journal of Molecular Sciences, 2022; 23(9):4551-1-4551-20 |
Publisher: | MDPI AG |
Issue Date: | 2022 |
ISSN: | 1661-6596 1422-0067 |
Statement of Responsibility: | Anya L. Arthurs, Tanja Jankovic-Karasoulos, Melanie D. Smith and Claire T. Roberts |
Abstract: | The emerging field of circular RNAs (circRNAs) has identified their novel roles in the development and function of many cancers and inspired the interest of many researchers. circRNAs are also found throughout the healthy body, as well as in other pathological states, but while research into the function and abundance of circRNAs has progressed, our overall understanding of these molecules remains primitive. Importantly, recent studies are elucidating new roles for circRNAs in pregnancy, particularly in the placenta. Given that many of the genes responsible for circRNA production in cancer are also highly expressed in the placenta, it is likely that the same genes act in the production of circRNAs in the placenta. Furthermore, placental development can be referred to as ‘controlled cancer’, as it shares many key signalling pathways and hallmarks with tumour growth and metastasis. Hence, the roles of circRNAs in this field are important to study with respect to pregnancy success but also may provide novel insights for cancer progression. This review illuminates the known roles of circRNAs in pregnancy and the placenta, as well as demonstrating differential placental expressions of circRNAs between complicated and uncomplicated pregnancies. |
Keywords: | circular RNA circRNA pregnancy reproduction placenta |
Rights: | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). |
DOI: | 10.3390/ijms23094551 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/GNT1174971 |
Published version: | http://dx.doi.org/10.3390/ijms23094551 |
Appears in Collections: | Obstetrics and Gynaecology publications |
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hdl_135184.pdf | Published version | 815.43 kB | Adobe PDF | View/Open |
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