Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/133838
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Type: | Journal article |
Title: | Brain transcriptomes of zebrafish and mouse Alzheimer's disease knock-in models imply early disrupted energy metabolism |
Author: | Barthelson, K. Newman, M. Lardelli, M. |
Citation: | Disease Models and Mechanisms, 2022; 15(1):1-14 |
Publisher: | Company of Biologists |
Issue Date: | 2022 |
ISSN: | 1754-8403 1754-8411 |
Statement of Responsibility: | Karissa Barthelson, Morgan Newman, Michael Lardelli |
Abstract: | Energy production is the most fundamentally important cellular activity supporting all other functions, particularly in highly active organs such as brains, Here we summarise transcriptome analyses of young adult (pre-disease) brains from a collection of eleven early-onset familial Alzheimer’s disease (EOfAD)-like and non-EOfAD-like mutations in three zebrafish genes. The one cellular activity consistently predicted as affected by only the EOfAD-like mutations is oxidative phosphorylation that produces most of the brain’s energy. All the mutations were predicted to affect protein synthesis. We extended our analysis to knock-in mouse models of APOE alleles and found the same effect for the late onset Alzheimer’s disease risk allele 4. Our results support a common molecular basis for initiation of the pathological processes leading to both early and late onset forms of Alzheimer’s disease and illustrate the utility of zebrafish and of knock-in, single EOfAD mutation models for understanding the causes of this disease. |
Keywords: | Alzheimer’s disease; zebrafish; mouse; RNA-seq; oxidative phosphorylation; brain |
Description: | Accepted manuscript |
Rights: | © 2021. Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
DOI: | 10.1242/dmm.049187 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/GNT1061006 http://purl.org/au-research/grants/nhmrc/GNT1126422 |
Published version: | http://dx.doi.org/10.1242/dmm.049187 |
Appears in Collections: | Genetics publications |
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hdl_133838.pdf | Published version | 2.27 MB | Adobe PDF | View/Open |
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