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https://hdl.handle.net/2440/133045
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Type: | Journal article |
Title: | Evolution, expression and meiotic behavior of genes involved in chromosome segregation of monotremes |
Author: | Pajpach, F. Shearwin-Whyatt, L. Grutzner, F. |
Citation: | Genes, 2021; 12(9):1-17 |
Publisher: | MDPI |
Issue Date: | 2021 |
ISSN: | 2073-4425 2073-4425 |
Statement of Responsibility: | Filip Pajpach, Linda Shearwin-Whyatt and Frank Grützner |
Abstract: | Chromosome segregation at mitosis and meiosis is a highly dynamic and tightly regulated process that involves a large number of components. Due to the fundamental nature of chromosome segregation, many genes involved in this process are evolutionarily highly conserved, but duplications and functional diversification has occurred in various lineages. In order to better understand the evolution of genes involved in chromosome segregation in mammals, we analyzed some of the key components in the basal mammalian lineage of egg-laying mammals. The chromosome passenger complex is a multiprotein complex central to chromosome segregation during both mitosis and meiosis. It consists of survivin, borealin, inner centromere protein, and Aurora kinase B or C. We confirm the absence of Aurora kinase C in marsupials and show its absence in both platypus and echidna, which supports the current model of the evolution of Aurora kinases. High expression of AURKBC, an ancestor of AURKB and AURKC present in monotremes, suggests that this gene is performing all necessary meiotic functions in monotremes. Other genes of the chromosome passenger complex complex are present and conserved in monotremes, suggesting that their function has been preserved in mammals. Cohesins are another family of genes that are of vital importance for chromosome cohesion and segregation at mitosis and meiosis. Previous work has demonstrated an accumulation and differential loading of structural maintenance of chromosomes 3 (SMC3) on the platypus sex chromosome complex at meiotic prophase I. We investigated if a similar accumulation occurs in the echidna during meiosis I. In contrast to platypus, SMC3 was only found on the synaptonemal complex in echidna. This indicates that the specific distribution of SMC3 on the sex chromosome complex may have evolved specifically in platypus. |
Keywords: | Aurora kinase; chromosome passenger complex; cohesin; monotreme; meiosis; sex chromosome multiple |
Rights: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). |
DOI: | 10.3390/genes12091320 |
Grant ID: | http://purl.org/au-research/grants/arc/FT160100267 http://purl.org/au-research/grants/arc/FT160100267 |
Published version: | http://dx.doi.org/10.3390/genes12091320 |
Appears in Collections: | Genetics publications |
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hdl_133045.pdf | Published version | 4.8 MB | Adobe PDF | View/Open |
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