Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/132720
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Type: | Journal article |
Title: | Transplant tolerance induction: insights from the liver |
Author: | Dai, H. Zheng, Y. Thomson, A.W. Rogers, N.M. |
Citation: | Frontiers in Immunology, 2020; 11:1044-1-1044-14 |
Publisher: | Frontiers Media |
Issue Date: | 2020 |
ISSN: | 1664-3224 1664-3224 |
Statement of Responsibility: | Helong Dai, Yawen Zheng, Angus W. Thomson and Natasha M. Rogers |
Abstract: | A comparison of pre-clinical transplant models and of solid organs transplanted in routine clinical practice demonstrates that the liver is most amenable to the development of immunological tolerance. This phenomenon arises in the absence of stringent conditioning regimens that accompany published tolerizing protocols for other organs, particularly the kidney. The unique immunologic properties of the liver have assisted our understanding of the alloimmune response and how it can be manipulated to improve graft function and survival. This review will address important findings following liver transplantation in both animals and humans, and how these have driven the understanding and development of therapeutic immunosuppressive options. We will discuss the liver's unique system of immune and non-immune cells that regulate immunity, yet maintain effective responses to pathogens, as well as mechanisms of liver transplant tolerance in pre-clinical models and humans, including current immunosuppressive drug withdrawal trials and biomarkers of tolerance. In addition, we will address innovative therapeutic strategies, including mesenchymal stem cell, regulatory T cell, and regulatory dendritic cell therapy to promote liver allograft tolerance or minimization of immunosuppression in the clinic. |
Keywords: | Liver transplantation; immune tolerance; mechanisms; cell therapy; immunosuppression withdrawal |
Rights: | © 2020 Dai, Zheng, Thomson and Rogers. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
DOI: | 10.3389/fimmu.2020.01044 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/GNT1158977 http://purl.org/au-research/grants/nhmrc/GNT1138372 |
Published version: | http://dx.doi.org/10.3389/fimmu.2020.01044 |
Appears in Collections: | Medicine publications |
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